Happy Heart

Happy Heart Advanced

A two-capsule daily formula built around 200 mg of coenzyme Q10 and 200 mg of magnesium, with the B vitamins that regulate homocysteine and selenium. Complements, and does not replace, prescribed cardiovascular care. Pre-order. Made in small batches. Your order reserves a place in the next production run, which ships approximately 8 weeks after the batch is confirmed. Full refund any time before shipping.

$89 30 day supply

Add to cart, $89

30 day supply, 60 capsules, two per day
Made in an NSF GMP-certified facility, each batch third-party tested
Vegan capsules, clean label, no CBD or THC
Free shipping on orders over 100 dollars

Intended to complement, not replace, prescribed cardiovascular care. Coenzyme Q10 may interact with blood-thinning medication. If you take prescription medication, speak with your healthcare provider before use.

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Scientific Overview

Happy Heart Advanced is built around coenzyme Q10, the electron carrier that mitochondria use to produce ATP. Heart muscle has one of the highest mitochondrial densities of any tissue. Advanced supplies 200 mg of CoQ10 as ubiquinone in two daily capsules, with folate, vitamin B12, vitamin B6, and riboflavin in active forms and selenium. Randomized trials of CoQ10 have used 100 to 300 mg per day; results for blood pressure are mixed, and the largest outcome trial was conducted in adults under medical care for heart failure, not in healthy adults. Advanced also supplies 200 mg of magnesium as buffered bisglycinate chelate, the same amount as Happy Heart Core. The formula itself has not been tested in a controlled trial.

Benefits

Supplies 200 mg of coenzyme Q10 as ubiquinone
Supports mitochondrial energy production
Supports normal homocysteine metabolism with folate, B12, B6, and riboflavin in active forms
Selenium supports the antioxidant enzyme glutathione peroxidase
Supplies 200 mg of magnesium as buffered bisglycinate chelate

How it works

01
Coenzyme Q10 carries electrons between complexes of the mitochondrial electron transport chain, the step that drives ATP production. The body makes CoQ10 through the same pathway that produces cholesterol.
02
Folate, vitamin B12, vitamin B6, and riboflavin are the cofactors of the methylation cycle that clears homocysteine. Advanced supplies folate as Quatrefolic® 5-MTHF, which does not require enzymatic activation.
03
Selenium is required for glutathione peroxidase. Controlled trials have not shown that selenium supplementation prevents cardiovascular disease, and no such claim is made here.

Ingredients

Coenzyme Q10, 200 mg As ubiquinone. Electron carrier in mitochondrial ATP production

Magnesium, 200 mg As buffered magnesium bisglycinate chelate. Enzymatic cofactor for vascular tone and cardiac rhythm

Folate, 680 mcg DFE 400 mcg as Quatrefolic® 5-MTHF. Methylation and homocysteine metabolism

Vitamin B12, 500 mcg As methylcobalamin. Methylation and nerve function

Vitamin B6, 10 mg As pyridoxal-5′-phosphate. Homocysteine metabolism

Riboflavin (B2), 5 mg As riboflavin-5′-phosphate. Cofactor in folate metabolism

Pantothenic acid (B5), 10 mg As calcium pantothenate. Precursor of coenzyme A

Selenium, 100 mcg As L-selenomethionine. Required for glutathione peroxidase

Vitamin D3, 1.25 mcg (50 IU) As cholecalciferol. A small amount, 6% of the Daily Value

Research references

Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO. JACC Heart Fail. 2014;2(6):641–649.
Ho MJ, Li ECK, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016;3:CD007435.
Homocysteine Lowering Trialists’ Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine. Am J Clin Nutr. 2005;82(4):806–812.
Martí-Carvajal AJ, et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612.
Rees K, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;(1):CD009671.

Reference summaries shown by topic. Full citations are published in the Research References library.

Scientific disclaimer: these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Solprana formulations are designed to complement, not replace, care prescribed by a qualified healthcare provider. Consult your provider before beginning any supplement, particularly if you take prescription medication, are pregnant or are nursing.