Happy Heart Plus
- 30 day supply, 90 capsules, three per day
- Made in an NSF GMP-certified facility, each batch third-party tested
- Vegan capsules, clean label, no CBD or THC
- Free shipping on orders over 100 dollars
Intended to complement, not replace, prescribed cardiovascular care. Coenzyme Q10 may interact with blood-thinning medication. If you take prescription medication, speak with your healthcare provider before use.
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Happy Heart Plus adds two redox ingredients to the Happy Heart Advanced formula: 600 mg of N-acetylcysteine and 100 mg of alpha-lipoic acid, alongside 200 mg of coenzyme Q10. N-acetylcysteine supplies cysteine, the rate-limiting substrate for glutathione synthesis. Alpha-lipoic acid is a cofactor of mitochondrial dehydrogenase enzymes and takes part in antioxidant recycling. Clinical trials of alpha-lipoic acid have mostly used 600 mg per day, six times the amount in Plus. Plus also supplies 200 mg of magnesium as buffered bisglycinate chelate, the same amount as Happy Heart Core. The formula itself has not been tested in a controlled trial.
Benefits
- Supplies 200 mg of coenzyme Q10 as ubiquinone
- Supplies 600 mg of N-acetylcysteine, a precursor of glutathione
- Supplies 100 mg of alpha-lipoic acid
- Supports normal homocysteine metabolism with folate, B12, B6, and riboflavin in active forms
- Selenium supports the antioxidant enzyme glutathione peroxidase
How it works
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01
N-acetylcysteine supplies cysteine, the rate-limiting substrate for the body's own glutathione synthesis.
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02
Alpha-lipoic acid is a cofactor of mitochondrial dehydrogenase enzymes, works in both water-soluble and fat-soluble environments, and takes part in the regeneration of other antioxidants.
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03
Coenzyme Q10 carries electrons between complexes of the mitochondrial electron transport chain, the step that drives ATP production.
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04
Folate, vitamin B12, vitamin B6, and riboflavin are the cofactors of the methylation cycle that clears homocysteine.
Ingredients
Research references
- Atkuri KR, et al. N-Acetylcysteine: a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007;7(4):355–359.
- Shay KP, et al. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta. 2009;1790(10):1149–1160.
- Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO. JACC Heart Fail. 2014;2(6):641–649.
- Ho MJ, Li ECK, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016;3:CD007435.
- Homocysteine Lowering Trialists’ Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine. Am J Clin Nutr. 2005;82(4):806–812.
- Martí-Carvajal AJ, et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612.
- Rees K, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2013;(1):CD009671.
Reference summaries shown by topic. Full citations are published in the Research References library.
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Scientific disclaimer: these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Solprana formulations are designed to complement, not replace, care prescribed by a qualified healthcare provider. Consult your provider before beginning any supplement, particularly if you take prescription medication, are pregnant or are nursing.