Every Solprana product begins with a whitepaper, not a formula. This library holds the research and reasoning behind that process — including where the evidence is strong, where it’s still developing, and where findings didn’t support a hypothesis. Nothing here is edited to fit a product that was already decided on.
Section 1: Foundational Framework
A conceptual framework proposing that four environmental conditions — toxin burden, nutritional sufficiency, hydration, and mental stability — govern cellular energy production and long-term physiological resilience. This is the scientific foundation underlying every Solprana product system.
Section 2: Whitepapers
Cholesterol-Lowering Therapy, Mitochondrial Stress, and Nutrient Restoration
Examines how cholesterol-lowering therapy intersects with CoQ10 synthesis and mitochondrial energy production. Frames nutritional support as complementary, not a replacement for prescribed treatment.
Cannabis Use and Long-Term Health
A cardiovascular-risk-centered look at how long-term cannabis use interacts with autonomic, vascular, and metabolic regulatory systems.
Pre-Ingestion Physiological Conditioning and Micronutrient Absorption Variability
Examines hydration, gastric emptying, and GI perfusion as variables in oral micronutrient absorption, and proposes a two-step delivery model.
From Fuel to Signal: Migraine Bioenergetics
Explores adenine nucleotide pool capacity and the adenosine A1 receptor as a potential endogenous brake on cortical spreading depression.
PTSD and Bioenergetic Restoration
An evidence-tiered review of magnesium, glutathione, and mitochondrial function in trauma physiology — explicit about where the research gap remains unresolved.
Section 3: Articles
Proposes that magnesium status modifies cardiac tolerance to cannabis under physical load, through competing demand on a shared magnesium pool rather than depletion. Presented as a hypothesis, with the findings that weaken it retained and the study that would test it described.
Happy Health Core and the Nutrient Gaps It Closes
Sets out the published intake data behind the formula, what is and is not shown in regular cannabis users, and how any individual can test the outcome with standard laboratory measures.
The Body Is Not a Calorie Counter
Describes a functional model of nutrition: what the body must have available, beyond elemental composition and energy totals, to turn food into biological work.
Nutrient Status Is Rarely Measured in Chronic Pain, Fatigue, and Traumatic Stress
Sets out what has been observed about nutrient status in chronic pain, fatigue, and traumatic stress, what has not been shown, and the study that would test it.
What Grandma’s Soup Supplied and Ultra-Processed Food Does Not
Examines what traditional soup has been shown to do, what was in the pot, and what the evidence does and does not say about the shift to ultra-processed food.
Bioavailability: Why the Dose on the Label Is Not the Dose You Absorb
Explains the difference between the amount of a nutrient on a supplement label and the fraction that is absorbed, and what controlled human studies show about form, dose, meals and hydration.
Frequent Cannabis Users Show Lower Vitamin D in Two Studies. The Cause Is Not Yet Known.
Reviews two independent studies that found lower circulating vitamin D in frequent cannabis users, what each measured, and why the cause cannot yet be determined.
Multivitamin/Mineral Supplementation: Energy, Subjective Outcomes, and Biological Biomarkers
Reviews the Dodd et al. (2020) trial of multivitamin/mineral supplementation, including its energy, subjective and biomarker outcomes, and the B-vitamin rationale behind it.
Magnesium, Cannabis, and the Quiet Loss of Stability
Examines why regular cannabis use may increase the body’s demand for magnesium, and what that could mean for physiological stability.
The Low-Carb vs. Low-Fat Debate Just Ended
Looks at a 30-year study of nearly 200,000 people in which heart health tracked diet quality rather than macronutrient ratio, and the biology behind that finding.
Mitochondria and the Real Source of Daily Energy
Describes how cells produce energy in the mitochondria and why that production depends on the presence of the required nutrient cofactors.
Cardiovascular Nutrition and the Long View
Sets out why cardiovascular nutrition should be judged over years rather than weeks, and why modest, sustainable daily habits matter more than short intensive protocols.
Electrolytes Beyond Hydration: Minerals as Regulators
Explains the role of sodium, potassium and magnesium as regulators of nerve, muscle and cellular activity, beyond their familiar association with hydration.